Version 5.4
Mus musculus Protein: Nrxn3
Summary
InnateDB Protein IDBP-160968.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrxn3
Protein Name neurexin III
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000050075
InnateDB Gene IDBG-160964 (Nrxn3)
Protein Structure
UniProt Annotation
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Brain and arteries (at protein level). {ECO:0000269PubMed:19926856}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly
GO:0051965 positive regulation of synapse assembly
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0016021 integral component of membrane
GO:0042734 presynaptic membrane
Protein Structure and Domains
PDB ID MGI:1096389
InterPro IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR003585 Neurexin/syndecan/glycophorin C
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00008
PF00054
PF02210
PRINTS
PIRSF
SMART SM00181
SM00210
SM00282
SM00294
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P9K9
PhosphoSite PhosphoSite-Q6P9K9
TrEMBL O88724
UniProt Splice Variant
Entrez Gene 18191
UniGene Mm.483090
RefSeq NP_766132
MGI ID 3MW4
MGI Symbol Nrxn3
OMIM
CCDS CCDS49134
HPRD
IMGT
EMBL AC115709 AC115744 AC115910 AC120383 AC154495 AC155231 AC155274 AC156637 AC161049 AC171335 AJ006804 AK032126 BC060719 CAAA01025627 CR974428 CR974583 CT009613 CT009725 CT010588 CU041252
GenPept AAH60719 BAC27716 CAA07259

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca