Version 5.4
Mus musculus Gene: Nrxn3
Summary
InnateDB Gene IDBG-160964.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrxn3
Gene Name neurexin III
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000066392
Encoded Proteins
IDBP-160968
neurexin III
IDBP-260921
neurexin III
IDBP-260935
neurexin III
IDBP-621524
neurexin III
IDBP-621525
neurexin III
IDBP-621529
neurexin III
IDBP-788708
neurexin III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:88722876-90334935
Strand Forward strand
Band D3
Transcripts
ENSMUST00000057634 ENSMUSP00000050075
ENSMUST00000110138
ENSMUST00000110133 ENSMUSP00000105760
ENSMUST00000110130 ENSMUSP00000105757
ENSMUST00000167734
ENSMUST00000167103 ENSMUSP00000127407
ENSMUST00000163944
ENSMUST00000163134 ENSMUSP00000129678
ENSMUST00000164072
ENSMUST00000170533
ENSMUST00000167887 ENSMUSP00000127926
ENSMUST00000190626 ENSMUSP00000139879
ENSMUST00000190030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly
GO:0007612 learning
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0051965 positive regulation of synapse assembly
GO:0071625 vocalization behavior
GO:0090129 positive regulation of synapse maturation
Cellular Component
GO:0016021 integral component of membrane
GO:0042734 presynaptic membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000021645
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q8C985
TrEMBL O88724 Q3V3R0
UniProt Splice Variant
Entrez Gene 18191
UniGene Mm.408668 Mm.422334 Mm.425766 Mm.461091 Mm.472156 Mm.483090
RefSeq NM_001252074 NM_001198587 NM_172544 XM_006515555 XM_006515556 XM_006515557 XM_006515558 XM_006515559 XM_006515563
OMIM
CCDS CCDS49134 CCDS56856
HPRD
IMGT
MGI ID MGI:1096389
MGI Symbol Nrxn3
EMBL AC115709 AC115744 AC115910 AC120383 AC154495 AC155231 AC155274 AC156637 AC161049 AC171335 AJ006804 AK036342 AK042730 CAAA01025627 CR974428 CR974583 CT009613 CT009725 CT010588 CU041252
GenPept BAC31344 BAE20501 CAA07259
RNA Seq Atlas 18191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca