InnateDB Protein
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IDBP-161045.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tet3
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Protein Name
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tet oncogene family member 3
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000087049
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InnateDB Gene
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IDBG-161043 (Tet3)
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Protein Structure
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Function |
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269PubMed:20639862, ECO:0000269PubMed:21407207, ECO:0000269PubMed:21778364, ECO:0000269PubMed:21892189, ECO:0000269PubMed:22722204}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21892189}. Cytoplasm {ECO:0000269PubMed:21892189}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages.
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Disease Associations |
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Tissue Specificity |
Highly expressed in oocytes and zygotes. Not expressed in embryonic stem cells (ES cells). {ECO:0000269PubMed:20639862, ECO:0000269PubMed:21321204, ECO:0000269PubMed:21407207, ECO:0000269PubMed:21892189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2446229
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BG87
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PhosphoSite |
PhosphoSite-Q8BG87
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
194388
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UniGene |
Mm.486317
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RefSeq |
NP_898961
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MGI ID |
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MGI Symbol |
Tet3
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OMIM |
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CCDS |
CCDS51820
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HPRD |
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IMGT |
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EMBL |
AC090648
AC159713
AK044758
AK046543
AK046552
AK046553
BC096437
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GenPept |
AAH96437
BAC32068
BAC32779
BAC32784
BAC32785
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