InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamtor2

Summary

InnateDB Protein

IDBP-161207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamtor2

Protein Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

Synonyms

2010111E04Rik; AL022628; Mapbpip; P14; Rab25; Robld3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029698

InnateDB Gene

IDBG-161205 (Lamtor2)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269PubMed:15263099}.

Subcellular Localization

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11266467}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0000186	activation of MAPKK activity
GO:0016049	cell growth
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0071230	cellular response to amino acid stimulus