Version 5.4
Mus musculus Gene: Lamtor2
Summary
InnateDB Gene IDBG-161205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lamtor2
Gene Name late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Synonyms 2010111E04Rik; AL022628; Mapbpip; P14; Rab25; Robld3
Species Mus musculus
Ensembl Gene ENSMUSG00000028062
Encoded Proteins
IDBP-161207
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
IDBP-401140
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116586:
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:88549819-88553074
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029698 ENSMUSP00000029698
ENSMUST00000119002 ENSMUSP00000112936
ENSMUST00000145548
ENSMUST00000156421
ENSMUST00000145172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000186 activation of MAPKK activity
GO:0016049 cell growth
GO:0032008 positive regulation of TOR signaling
GO:0034613 cellular protein localization
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0070062 extracellular vesicular exosome
GO:0071986 Ragulator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116586
View Gene Order
ENSBTAG00000011754
Not yet available
Cross-References
SwissProt
TrEMBL D3YTS4
UniProt Splice Variant
Entrez Gene 83409
UniGene
RefSeq NM_031248
OMIM
CCDS CCDS17478
HPRD
IMGT
MGI ID MGI:1932697
MGI Symbol Lamtor2
EMBL AC145168
GenPept
RNA Seq Atlas 83409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca