Mus musculus Protein: Fbxl5 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-161239.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Fbxl5 | ||||||
Protein Name | F-box and leucine-rich repeat protein 5 | ||||||
Synonyms | |||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000045792 | ||||||
InnateDB Gene | IDBG-161237 (Fbxl5) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). {ECO:0000250}. | ||||||
Subcellular Localization | Cytoplasm, perinuclear region {ECO:0000250}. | ||||||
Disease Associations | |||||||
Tissue Specificity | |||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:2152883 | ||||||
InterPro |
IPR001611
Leucine-rich repeat IPR001810 F-box domain IPR006553 Leucine-rich repeat, cysteine-containing subtype |
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PFAM |
PF00560
PF13504 PF13855 PF00646 PF12937 PF13013 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00256
SM00367 |
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q8C2S5 | ||||||
PhosphoSite | PhosphoSite-Q8C2S5 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 242960 | ||||||
UniGene | Mm.457823 | ||||||
RefSeq | NP_001153435 | ||||||
MGI ID | |||||||
MGI Symbol | Fbxl5 | ||||||
OMIM | |||||||
CCDS | CCDS51489 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AK029957 AK041497 AK082931 AK085100 AK088067 AK150664 AK159744 AK171783 BC047214 BC113798 | ||||||
GenPept | AAH47214 AAI13799 BAC26698 BAC30964 BAC38698 BAC39366 BAC40126 BAE29748 BAE35337 BAE42662 | ||||||