InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Apoa5

Summary

InnateDB Protein

IDBP-161350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoa5

Protein Name

apolipoprotein A-V

Synonyms

1300007O05Rik; Apoav; RAP3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034584

InnateDB Gene

IDBG-161348 (Apoa5)

Protein Structure

UniProt Annotation

Function

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11577099}.

Disease Associations

Tissue Specificity

Liver. {ECO:0000269PubMed:11577099, ECO:0000269PubMed:11588264}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0031210	phosphatidylcholine binding
GO:0035473	lipase binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0009725	response to hormone
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling
GO:0019433	triglyceride catabolic process
GO:0031100	organ regeneration
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042246	tissue regeneration
GO:0042632	cholesterol homeostasis
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055090	acylglycerol homeostasis
GO:0070328	triglyceride homeostasis