InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apoa5

Summary

InnateDB Gene

IDBG-161348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Apoa5

Gene Name

apolipoprotein A-V

Synonyms

1300007O05Rik; Apoav; RAP3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032079

Encoded Proteins

IDBP-161350

apolipoprotein A-V

IDBP-401163

apolipoprotein A-V

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110243:
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:46268633-46271919

Strand

Forward strand

Band

A5.2

Transcripts

ENSMUST00000034584	ENSMUSP00000034584
ENSMUST00000121598	ENSMUSP00000113413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008047	enzyme activator activity
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0019899	enzyme binding
GO:0031210	phosphatidylcholine binding
GO:0035473	lipase binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0060229	lipase activator activity
GO:0060230	lipoprotein lipase activator activity
GO:0070325	lipoprotein particle receptor binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0009725	response to hormone
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling
GO:0019433	triglyceride catabolic process
GO:0031100	organ regeneration
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0042157	lipoprotein metabolic process
GO:0042246	tissue regeneration
GO:0042632	cholesterol homeostasis
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0050996	positive regulation of lipid catabolic process
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055090	acylglycerol homeostasis
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron