InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Creb1

Summary

InnateDB Protein

IDBP-161361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Creb1

Protein Name

cAMP responsive element binding protein 1

Synonyms

2310001E10Rik; 3526402H21Rik; AV083133; Creb; Creb-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059973

InnateDB Gene

IDBG-161359 (Creb1)

Protein Structure

UniProt Annotation

Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. {ECO:0000269PubMed:11970866, ECO:0000269PubMed:21728997}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00312, ECO:0000255PROSITE-ProRule:PRU00978, ECO:0000269PubMed:21728997}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:1387109}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 181 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	22 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	181 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035497	cAMP response element binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007595	lactation
GO:0007613	memory
GO:0007623	circadian rhythm
GO:0008361	regulation of cell size
GO:0010033	response to organic substance
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0021983	pituitary gland development
GO:0030879	mammary gland development
GO:0033363	secretory granule organization
GO:0033762	response to glucagon
GO:0040018	positive regulation of multicellular organism growth
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0045600	positive regulation of fat cell differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046887	positive regulation of hormone secretion
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050821	protein stabilization
GO:0060428	lung epithelium development
GO:0060430	lung saccule development
GO:0060509	Type I pneumocyte differentiation
GO:0071294	cellular response to zinc ion
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005719	nuclear euchromatin

Protein Structure and Domains

PDB ID

MGI:88494

InterPro

IPR001630 cAMP response element binding (CREB) protein
IPR003102 Coactivator CBP, pKID
IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF02173
PF00170
PF07716

PRINTS

PR00041

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt