InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ston2

Summary

InnateDB Protein

IDBP-161526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ston2

Protein Name

stonin 2

Synonyms

4933401N24Rik; AI425999; AW544599;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053908

InnateDB Gene

IDBG-161524 (Ston2)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Some fraction is membrane-associated.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007268	synaptic transmission
GO:0016192	vesicle-mediated transport
GO:0030100	regulation of endocytosis
GO:0048488	synaptic vesicle endocytosis

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:1918272

InterPro

IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR012320 Stonin homology
IPR017110 Stonin
IPR022699 Stonin-2, N-terminal
IPR028565 Mu homology domain

PFAM

PF00928
PF12016

PRINTS

PIRSF

PIRSF037099

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BZ60