InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif11

Summary

InnateDB Protein

IDBP-161599.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif11

Protein Name

kinesin family member 11

Synonyms

Eg5; Kif8; Kifl1; Knsl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000012587

InnateDB Gene

IDBG-161597 (Kif11)

Protein Structure

UniProt Annotation

Function

Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007051	spindle organization
GO:0007100	mitotic centrosome separation
GO:0008152	metabolic process
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0016020	membrane
GO:0072686	mitotic spindle