InnateDB Protein
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IDBP-161643.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Prom1
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Protein Name
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prominin 1
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Synonyms
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4932416E19Rik; AC133; CD133; Prom; Prom-1; Proml1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000084709
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InnateDB Gene
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IDBG-161637 (Prom1)
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Protein Structure
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Function |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. {ECO:0000269PubMed:19228982}.
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Subcellular Localization |
Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine.
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Disease Associations |
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Tissue Specificity |
In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level). {ECO:0000269PubMed:12514187, ECO:0000269PubMed:17874118, ECO:0000269PubMed:18654668, ECO:0000269PubMed:19228982}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1100886
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InterPro |
IPR008795
Prominin
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PFAM |
PF05478
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O54990
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PhosphoSite |
PhosphoSite-O54990
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19126
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UniGene |
Mm.6250
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RefSeq |
NP_001157055
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MGI ID |
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MGI Symbol |
Prom1
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OMIM |
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CCDS |
CCDS51493
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HPRD |
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IMGT |
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EMBL |
AF026269
AF039663
AF305215
AK030027
AY099088
AY223521
AY223522
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GenPept |
AAB86715
AAB96916
AAM28245
AAO11840
AAO72429
AAO72430
BAC26745
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