InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prom1

Summary

InnateDB Protein

IDBP-161645.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prom1

Protein Name

prominin 1

Synonyms

4932416E19Rik; AC133; CD133; Prom; Prom-1; Proml1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030973

InnateDB Gene

IDBG-161637 (Prom1)

Protein Structure

UniProt Annotation

Function

May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. {ECO:0000269PubMed:19228982}.

Subcellular Localization

Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine.

Disease Associations

Tissue Specificity

In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level). {ECO:0000269PubMed:12514187, ECO:0000269PubMed:17874118, ECO:0000269PubMed:18654668, ECO:0000269PubMed:19228982}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0010842	retina layer formation
GO:0060219	camera-type eye photoreceptor cell differentiation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005903	brush border
GO:0005929	cilium
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031528	microvillus membrane
GO:0032420	stereocilium
GO:0042995	cell projection
GO:0071914	prominosome