InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dock2

Summary

InnateDB Protein

IDBP-161696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dock2

Protein Name

dedicator of cyto-kinesis 2

Synonyms

AI662014; AW122239; CED-5; Hch; MBC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090884

InnateDB Gene

IDBG-161694 (Dock2)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269PubMed:11518968}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with F-actin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in hematopoietic cells. {ECO:0000269PubMed:11518968}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002277	myeloid dendritic cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035022	positive regulation of Rac protein signal transduction
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0044351	macropinocytosis
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2149010

InterPro

IPR001452 SH3 domain
IPR009056 Cytochrome c-like domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain
IPR016024 Armadillo-type fold

PFAM

PF00018
PF14604
PF13442
PF06920
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt