InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dock2

Summary

InnateDB Gene

IDBG-161694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dock2

Gene Name

dedicator of cyto-kinesis 2

Synonyms

AI662014; AW122239; CED-5; Hch; MBC

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020143

Encoded Proteins

IDBP-161696

dedicator of cyto-kinesis 2

IDBP-161698

dedicator of cyto-kinesis 2

IDBP-161700

dedicator of cyto-kinesis 2

IDBP-538065

dedicator of cyto-kinesis 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134516:
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:34226815-34783892

Strand

Reverse strand

Band

Transcripts

ENSMUST00000093193	ENSMUSP00000090884
ENSMUST00000101365	ENSMUSP00000098916
ENSMUST00000101364	ENSMUSP00000098915
ENSMUST00000127846
ENSMUST00000157036
ENSMUST00000143540	ENSMUSP00000116893
ENSMUST00000154178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0030675	Rac GTPase activator activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0002277	myeloid dendritic cell activation involved in immune response
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035022	positive regulation of Rac protein signal transduction
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0044351	macropinocytosis
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation
GO:0050766	positive regulation of phagocytosis