InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dock2

Summary

InnateDB Protein

IDBP-161698.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Dock2

Protein Name

dedicator of cyto-kinesis 2

Synonyms

AI662014; AW122239; CED-5; Hch; MBC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098916

InnateDB Gene

IDBG-161694 (Dock2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0001766	membrane raft polarization
GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0006935	chemotaxis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0035022	positive regulation of Rac protein signal transduction
GO:0042098	T cell proliferation
GO:0042110	T cell activation
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0046631	alpha-beta T cell activation
GO:0046633	alpha-beta T cell proliferation