InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Efnb1

Summary

InnateDB Protein

IDBP-161817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efnb1

Protein Name

ephrin B1

Synonyms

Cek5-L; EFL-3; Elk-L; Epl2; Eplg2; LERK-2; Lerk2; Stra1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050716

InnateDB Gene

IDBG-161815 (Efnb1)

Protein Structure

UniProt Annotation

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269PubMed:10704386}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on lateral floor plate cells, specifically on commissural axon segments that have passed through the floor plate. Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disc.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001755	neural crest cell migration
GO:0007411	axon guidance
GO:0009880	embryonic pattern specification
GO:0042102	positive regulation of T cell proliferation
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome