Version 5.4
Mus musculus Protein: Nagk
Summary
InnateDB Protein IDBP-161839.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nagk
Protein Name N-acetylglucosamine kinase
Synonyms Gnk;
Species Mus musculus
Ensembl Protein ENSMUSP00000042026
InnateDB Gene IDBG-161837 (Nagk)
Protein Structure
UniProt Annotation
Function Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity. {ECO:0000269PubMed:10824116}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10824116}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009384 N-acylmannosamine kinase activity
GO:0045127 N-acetylglucosamine kinase activity
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0019262 N-acetylneuraminate catabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1860418
InterPro IPR002731 ATPase, BadF/BadG/BcrA/BcrD type
PFAM PF01869
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZ08
PhosphoSite PhosphoSite-Q9QZ08
TrEMBL Q3U2G9
UniProt Splice Variant
Entrez Gene 56174
UniGene Mm.190650
RefSeq NP_062415
MGI ID
MGI Symbol Nagk
OMIM
CCDS CCDS20286
HPRD
IMGT
EMBL AJ242909 AK155292 BC004689 CH466523
GenPept AAH04689 BAE33171 CAB61849 EDK99109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca