InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx17

Summary

InnateDB Protein

IDBP-161890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx17

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

Synonyms

2610007K22Rik; A430025E01Rik; AI047725; C80929; Gm926; p72;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055535

InnateDB Gene

IDBG-161888 (Ddx17)

Protein Structure

UniProt Annotation

Function

RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation (By similarity). Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation. {ECO:0000250, ECO:0000269PubMed:17011493}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	90 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0030331	estrogen receptor binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0009791	post-embryonic development
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072358	cardiovascular system development
GO:2001014	regulation of skeletal muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1914290

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q501J6