Version 5.4
Mus musculus Gene: Ddx17
Summary
InnateDB Gene IDBG-161888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddx17
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Synonyms 2610007K22Rik; A430025E01Rik; AI047725; C80929; Gm926; p72
Species Mus musculus
Ensembl Gene ENSMUSG00000055065
Encoded Proteins
IDBP-161890
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:79527707-79546741
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000054014 ENSMUSP00000055535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 90 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0030331 estrogen receptor binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0009791 post-embryonic development
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0072358 cardiovascular system development
GO:2001014 regulation of skeletal muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100201
View Gene Order
ENSBTAG00000009887
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt Q501J6
TrEMBL Q3U6Y5 Q3U741 Q78W10
UniProt Splice Variant
Entrez Gene 67040
UniGene Mm.29644 Mm.474608
RefSeq NM_001040187 NM_199079 NM_199080 XM_006521290
OMIM
CCDS CCDS27643
HPRD
IMGT
MGI ID MGI:1914290
MGI Symbol Ddx17
EMBL AC117806 AK027954 AK039888 AK151061 AK152831 AK152910 BC062910 BC096036 CH466550
GenPept AAH62910 AAH96036 BAC25680 BAC30474 BAE30078 BAE31531 BAE31589 EDL04645
RNA Seq Atlas 67040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca