InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Galr1

Summary

InnateDB Protein

IDBP-161943.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galr1

Protein Name

galanin receptor 1

Synonyms

Galnr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066381

InnateDB Gene

IDBG-161941 (Galr1)

Protein Structure

UniProt Annotation

Function

Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004966	galanin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051464	positive regulation of cortisol secretion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1096364

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000405 Galanin receptor family
IPR000611 Neuropeptide Y receptor family
IPR003906 Galanin receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10323
PF10324

PRINTS

PR00237
PR00663
PR01012
PR01418

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56479