InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Galr1

Summary

InnateDB Gene

IDBG-161941.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galr1

Gene Name

galanin receptor 1

Synonyms

Galnr1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024553

Encoded Proteins

IDBP-161943

galanin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166573:
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:82392496-82406777

Strand

Reverse strand

Band

Transcripts

ENSMUST00000065224

ENSMUSP00000066381

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004966	galanin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0042923	neuropeptide binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051464	positive regulation of cortisol secretion