InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctsl

Summary

InnateDB Protein

IDBP-161959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsl

Protein Name

cathepsin L

Synonyms

1190035F06Rik; Ctsl1; fs; MEP; nkt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021933

InnateDB Gene

IDBG-161957 (Ctsl)

Protein Structure

UniProt Annotation

Function

Important for the overall degradation of proteins in lysosomes.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016807	cysteine-type carboxypeptidase activity
GO:0030984	kininogen binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0042393	histone binding

Biological Process

GO:0006508	proteolysis
GO:0007154	cell communication
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0010259	multicellular organismal aging
GO:0010839	negative regulation of keratinocyte proliferation
GO:0014070	response to organic cyclic compound
GO:0016485	protein processing
GO:0016540	protein autoprocessing
GO:0021675	nerve development
GO:0031069	hair follicle morphogenesis
GO:0034698	response to gonadotropin
GO:0042637	catagen
GO:0046697	decidualization
GO:0048102	autophagic cell death
GO:0051384	response to glucocorticoid
GO:0060008	Sertoli cell differentiation
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005773	vacuole
GO:0005902	microvillus
GO:0009897	external side of plasma membrane
GO:0030141	secretory granule
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome