InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dmc1

Summary

InnateDB Protein

IDBP-162061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dmc1

Protein Name

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)

Synonyms

Dmc1h; Lim15; Mei11; sgdp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023065

InnateDB Gene

IDBG-162059 (Dmc1)

Protein Structure

UniProt Annotation

Function

May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. {ECO:0000269PubMed:17639081}.

Subcellular Localization

Nucleus {ECO:0000305}. Chromosome {ECO:0000269PubMed:22549958}.

Disease Associations

Tissue Specificity

Testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000150	recombinase activity
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0001541	ovarian follicle development
GO:0001556	oocyte maturation
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007276	gamete generation
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009432	SOS response

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

MGI:105393

InterPro

IPR003593 AAA+ ATPase domain
IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
IPR011940 Meiotic recombinase Dmc1
IPR013632 DNA recombination and repair protein Rad51, C-terminal
IPR013765 DNA recombination and repair protein RecA
IPR014774 Circadian clock protein KaiC/DNA repair protein RadA
IPR016467 DNA recombination and repair protein, RecA-like
IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF08423
PF00154
PF06745

PRINTS

PR00142

PIRSF

PIRSF005856

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References