InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc2a8

Summary

InnateDB Protein

IDBP-162098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc2a8

Protein Name

solute carrier family 2, (facilitated glucose transporter), member 8

Synonyms

D2Ertd44e; GLUT8; GlutX1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028129

InnateDB Gene

IDBG-162096 (Slc2a8)

Protein Structure

UniProt Annotation

Function

Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005354	galactose transmembrane transporter activity
GO:0005355	glucose transmembrane transporter activity
GO:0005536	glucose binding
GO:0015284	fructose uniporter activity
GO:0022857	transmembrane transporter activity
GO:0022891	substrate-specific transmembrane transporter activity

Biological Process

GO:0001666	response to hypoxia
GO:0006006	glucose metabolic process
GO:0007141	male meiosis I
GO:0008286	insulin receptor signaling pathway
GO:0015755	fructose transport
GO:0015757	galactose transport
GO:0015758	glucose transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

MGI:1860103

InterPro

IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PR00171

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIF3