InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc7a8

Summary

InnateDB Protein

IDBP-162170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a8

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

Synonyms

AA408822; LAT2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022787

InnateDB Gene

IDBG-162168 (Slc7a8)

Protein Structure

UniProt Annotation

Function

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. {ECO:0000269PubMed:10574970}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000269PubMed:10574970}; Multi-pass membrane protein {ECO:0000269PubMed:10574970}. Note=Localized to the cytoplasm when expressed alone (By similarity). When coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in kidney and small intestine. Moderately present in placenta, ovary and brain. {ECO:0000269PubMed:10574970}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005275	amine transmembrane transporter activity
GO:0005515	protein binding
GO:0015101	organic cation transmembrane transporter activity
GO:0015171	amino acid transmembrane transporter activity
GO:0015179	L-amino acid transmembrane transporter activity
GO:0019534	toxin transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006865	amino acid transport
GO:0015695	organic cation transport
GO:0015807	L-amino acid transport
GO:0015837	amine transport
GO:0055085	transmembrane transport
GO:1901998	toxin transport
GO:1902475	L-alpha-amino acid transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome