InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr3b

Summary

InnateDB Protein

IDBP-162334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr3b

Protein Name

5-hydroxytryptamine (serotonin) receptor 3B

Synonyms

5-HT3B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008734

InnateDB Gene

IDBG-162332 (Htr3b)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269PubMed:12867984}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004993	serotonin receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005232	serotonin-activated cation-selective channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007210	serotonin receptor signaling pathway
GO:0034220	ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1861899

InterPro

IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008132 5-hydroxytryptamine 3 receptor
IPR008133 5-hydroxytryptamine 3 receptor, A subunit
IPR008134 5-hydroxytryptamine 3 receptor, B subunit

PFAM

PF02932
PF02931

PRINTS

PR00252
PR01708
PR01709
PR01710

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JHJ5