InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lap3

Summary

InnateDB Protein

IDBP-162364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lap3

Protein Name

leucine aminopeptidase 3

Synonyms

2410015L10Rik; AA410100; Lap; LAP-3; Lapep; Pep-7; Pep-S; Pep7; Peps;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040222

InnateDB Gene

IDBG-162362 (Lap3)

Protein Structure

UniProt Annotation

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008233	peptidase activity
GO:0008235	metalloexopeptidase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005802	trans-Golgi network
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1914238

InterPro

IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal
IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal
IPR011356 Leucine aminopeptidase/peptidase B

PFAM

PF00883
PF02789

PRINTS

PR00481

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CPY7