Version 5.4
Mus musculus Protein: Kif4
Summary
InnateDB Protein IDBP-162394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kif4
Protein Name kinesin family member 4
Synonyms AI323435; D330050K22Rik; Kns4;
Species Mus musculus
Ensembl Protein ENSMUSP00000048383
InnateDB Gene IDBG-162392 (Kif4)
Protein Structure
UniProt Annotation
Function Required for mitotic chromosomal positioning and bipolar spindle stabilization. {ECO:0000269PubMed:7929562}.
Subcellular Localization Nucleus {ECO:0000269PubMed:7929562}. Chromosome {ECO:0000269PubMed:7929562}. Cytoplasm, cytoskeleton {ECO:0000305PubMed:7929562}. Note=Associated with mitotic chromosomes.
Disease Associations
Tissue Specificity Expressed in pyramidal cells in juvenile hippocampus, granular cells in juvenile cerebellar cortex and in adult spleen. {ECO:0000269PubMed:7929562}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:108389
InterPro IPR001752 Kinesin, motor domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00225
PRINTS PR00380
PIRSF
SMART SM00129
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P33174
PhosphoSite PhosphoSite-P33174
TrEMBL
UniProt Splice Variant
Entrez Gene 16571
UniGene Mm.383091
RefSeq NP_032472
MGI ID 3ZFD
MGI Symbol Kif4
OMIM
CCDS CCDS30305
HPRD
IMGT
EMBL BC050946 BX005480 BX276129 CH466564 D12646
GenPept AAH50946 BAA02167 CAM15067 CAM17678 EDL14171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca