InnateDB Protein
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IDBP-162602.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zw10
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Protein Name
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ZW10 homolog (Drosophila), centromere/kinetochore protein
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Synonyms
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6330566F14Rik; MmZw10;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034803
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InnateDB Gene
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IDBG-162600 (Zw10)
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Protein Structure
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Function |
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (By similarity). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349478
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InterPro |
IPR009361
RZZ complex, subunit Zw10
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PFAM |
PF06248
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O54692
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PhosphoSite |
PhosphoSite-O54692
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26951
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UniGene |
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RefSeq |
NP_036169
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MGI ID |
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MGI Symbol |
Zw10
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OMIM |
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CCDS |
CCDS23161
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HPRD |
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IMGT |
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EMBL |
AF003951
AK145270
AK167251
AK167937
AK168479
BC012435
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GenPept |
AAB88256
AAH12435
BAE26337
BAE39372
BAE39941
BAE40368
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