InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zw10

Summary

InnateDB Gene

IDBG-162600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zw10

Gene Name

ZW10 homolog (Drosophila), centromere/kinetochore protein

Synonyms

6330566F14Rik; MmZw10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032264

Encoded Proteins

IDBP-162602

ZW10 homolog (Drosophila), centromere/kinetochore protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086827:
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:49055581-49078772

Strand

Forward strand

Band

A5.3

Transcripts

ENSMUST00000034803

ENSMUSP00000034803

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000132	establishment of mitotic spindle orientation
GO:0006461	protein complex assembly
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007067	mitotic nuclear division
GO:0007080	mitotic metaphase plate congression
GO:0007093	mitotic cell cycle checkpoint
GO:0007096	regulation of exit from mitosis
GO:0015031	protein transport
GO:0034501	protein localization to kinetochore

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005828	kinetochore microtubule
GO:0016020	membrane