InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Btla

Summary

InnateDB Protein

IDBP-162902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Btla

Protein Name

B and T lymphocyte associated

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099866

InnateDB Gene

IDBG-162900 (Btla)

Protein Structure

UniProt Annotation

Function

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in splenic T- and B-cells as well as lymph node tissues but very weakly in somatic tissues. Also expressed in macrophages, NK cells and dendritic cells. A polymorphic tissue distribution between several strains is seen. {ECO:0000269PubMed:12796776, ECO:0000269PubMed:15749870}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0030889	negative regulation of B cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0046642	negative regulation of alpha-beta T cell proliferation