Version 5.4
Mus musculus Gene: Btla
Summary
InnateDB Gene IDBG-162900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Btla
Gene Name B and T lymphocyte associated
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052013
Encoded Proteins
IDBP-162902
B and T lymphocyte associated
IDBP-162904
B and T lymphocyte associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186265:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:45224315-45252895
Strand Forward strand
Band B5
Transcripts
ENSMUST00000102802 ENSMUSP00000099866
ENSMUST00000063654 ENSMUSP00000067877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0030889 negative regulation of B cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0046642 negative regulation of alpha-beta T cell proliferation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000186265
View Gene Order
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7TSA3
TrEMBL
UniProt Splice Variant
Entrez Gene 208154
UniGene Mm.38199
RefSeq NM_177584 NM_001037719
OMIM
CCDS CCDS28196 CCDS28195
HPRD
IMGT
MGI ID MGI:2658978
MGI Symbol Btla
EMBL AK041334 AY293285
GenPept AAP44002 BAC30910
RNA Seq Atlas 208154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca