Version 5.4
Mus musculus Protein: Neto1
Summary
InnateDB Protein IDBP-162941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Neto1
Protein Name neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057340
InnateDB Gene IDBG-162939 (Neto1)
Protein Structure
UniProt Annotation
Function Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory. {ECO:0000269PubMed:12810072, ECO:0000269PubMed:19243221}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:19243221}. Note=Component of the postsynaptic density (PSD) of excitatory synapses.
Disease Associations
Tissue Specificity Expressed only in brain. Present throughout the central nervous system. Highly expressed in the hippocampal CA3 region, olfactory bulb and tubercle, caudate putamen, and neocortex in the adult brain. {ECO:0000269PubMed:12810072, ECO:0000269PubMed:15464227, ECO:0000269PubMed:19243221}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035255 ionotropic glutamate receptor binding
Biological Process
GO:0007613 memory
GO:0008542 visual learning
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0097120 receptor localization to synapse
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0032983 kainate selective glutamate receptor complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
Protein Structure and Domains
PDB ID MGI:2180216
InterPro IPR000859 CUB domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
PFAM PF00431
PF00057
PRINTS PR00261
PIRSF
SMART SM00042
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R4I7
PhosphoSite PhosphoSite-Q8R4I7
TrEMBL
UniProt Splice Variant
Entrez Gene 246317
UniGene
RefSeq NP_659195
MGI ID
MGI Symbol Neto1
OMIM
CCDS CCDS29387
HPRD
IMGT
EMBL AF448840 AK032510 AK081325 AY138990 BC051145
GenPept AAH51145 AAM18028 AAN38318 BAC27902 BAC38196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca