InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lgi1

Summary

InnateDB Protein

IDBP-162950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgi1

Protein Name

leucine-rich repeat LGI family, member 1

Synonyms

BB130740;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084507

InnateDB Gene

IDBG-162948 (Lgi1)

Protein Structure

UniProt Annotation

Function

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15857855, ECO:0000269PubMed:16787412}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 and isoform 2 are detected in the cytosolic and microsomal fractions respectively.

Disease Associations

Tissue Specificity

Brain. {ECO:0000269PubMed:16787412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007411	axon guidance
GO:0030307	positive regulation of cell growth
GO:0031175	neuron projection development
GO:0050806	positive regulation of synaptic transmission
GO:0051260	protein homooligomerization

Cellular Component

GO:0005615	extracellular space
GO:0030054	cell junction
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1861691

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
IPR009039 EAR
IPR017986 WD40-repeat-containing domain

PFAM

PF01463
PF00560
PF13504
PF13855
PF03736

PRINTS

PIRSF

SMART

SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIA1