InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spr

Summary

InnateDB Protein

IDBP-163015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spr

Protein Name

sepiapterin reductase

Synonyms

AA409688; ENSMUSG00000071345; Gm10328;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048111

InnateDB Gene

IDBG-163013 (Spr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004757	sepiapterin reductase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006558	L-phenylalanine metabolic process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0006809	nitric oxide biosynthetic process
GO:0008152	metabolic process
GO:0016265	death
GO:0019889	pteridine metabolic process
GO:0040014	regulation of multicellular organism growth
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0046146	tetrahydrobiopterin metabolic process
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050882	voluntary musculoskeletal movement
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:103078

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR006393 Sepiapterin reductase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt