InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crlf1

Summary

InnateDB Protein

IDBP-163171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crlf1

Protein Name

cytokine receptor-like factor 1

Synonyms

CLF-1; CRLM3; NR6.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008032

InnateDB Gene

IDBG-163169 (Crlf1)

Protein Structure

UniProt Annotation

Function

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development (By similarity). Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice. {ECO:0000250, ECO:0000269PubMed:10359701}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in the embryo. Not detected in the brain of adult mice. {ECO:0000269PubMed:10359701}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001657	ureteric bud development
GO:0008284	positive regulation of cell proliferation
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:2000672	negative regulation of motor neuron apoptotic process