Version 5.4
Mus musculus Gene: Crlf1
Summary
InnateDB Gene IDBG-163169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crlf1
Gene Name cytokine receptor-like factor 1
Synonyms CLF-1; CRLM3; NR6.1
Species Mus musculus
Ensembl Gene ENSMUSG00000007888
Encoded Proteins
IDBP-163171
cytokine receptor-like factor 1
IDBP-542658
cytokine receptor-like factor 1
IDBP-539277
cytokine receptor-like factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006016:
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70493158-70504081
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000008032 ENSMUSP00000008032
ENSMUST00000132648 ENSMUSP00000119545
ENSMUST00000127983 ENSMUSP00000115614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001657 ureteric bud development
GO:0008284 positive regulation of cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524 negative regulation of neuron apoptotic process
GO:2000672 negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0097058 CRLF-CLCF1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006016
View Gene Order
ENSBTAG00000007741
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.335584
RefSeq NM_018827 XM_006509540
OMIM
CCDS CCDS22369
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca