Version 5.4
Mus musculus Protein: Kcnip4
Summary
InnateDB Protein IDBP-163193.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnip4
Protein Name Kv channel interacting protein 4
Synonyms AV032399; Calp; Calp250; KChIP4; KChIP4a;
Species Mus musculus
Ensembl Protein ENSMUSP00000098776
InnateDB Gene IDBG-163191 (Kcnip4)
Protein Structure
UniProt Annotation
Function Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND3/Kv4.3 and KCND2/Kv4.2 currents (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11847232}; Peripheral membrane protein {ECO:0000269PubMed:11847232}.
Disease Associations
Tissue Specificity Expressed in brain. Highly expressed by neurons in layers II-IV of cortex and in hippocampus, thalamus and the Purkinje cell layer of the cerebellum. {ECO:0000269PubMed:11805342, ECO:0000269PubMed:11847232, ECO:0000269PubMed:15363885}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
GO:0005509 calcium ion binding
Biological Process
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:1933131
InterPro IPR002048 EF-hand domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00036
PF13202
PF13405
PF10591
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PHZ8
PhosphoSite PhosphoSite-Q6PHZ8
TrEMBL Q3V060
UniProt Splice Variant
Entrez Gene 80334
UniGene Mm.160172
RefSeq
MGI ID 3DD4
MGI Symbol Kcnip4
OMIM
CCDS
HPRD
IMGT
EMBL AF305071 AF453243 AK039048 AK133416 AY647240 BC051130 CH466524 CK618709
GenPept AAG36976 AAH51130 AAL86766 AAT68466 BAC30218 BAE21645 EDL37638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca