InnateDB Protein
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IDBP-163344.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Foxo4
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Protein Name
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forkhead box O4
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Synonyms
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afx; Afxh; Mllt7;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059420
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InnateDB Gene
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IDBG-163340 (Foxo4)
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Protein Structure
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Function |
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity). Represses smooth muscle cell differentiation by inhibiting the transcriptional coactivator activity of myocardin. {ECO:0000250, ECO:0000269PubMed:16054032}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in brown adipose tissue and weakly in white adipose tissue (at protein level). Expressed in skeletal muscle. {ECO:0000269PubMed:11353388, ECO:0000269PubMed:22510882}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1891915
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WVH3
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PhosphoSite |
PhosphoSite-Q9WVH3
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TrEMBL |
B1AUT3
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UniProt Splice Variant |
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Entrez Gene |
54601
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UniGene |
Mm.240299
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RefSeq |
NP_061259
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MGI ID |
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MGI Symbol |
Foxo4
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OMIM |
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CCDS |
CCDS41077
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HPRD |
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IMGT |
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EMBL |
AB032770
AF114260
BC139275
BC139304
CH466564
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GenPept |
AAD42108
AAI39276
AAI39305
BAA86199
EDL14154
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