InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxo4

Summary

InnateDB Gene

IDBG-163340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxo4

Gene Name

forkhead box O4

Synonyms

afx; Afxh; Mllt7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042903

Encoded Proteins

IDBP-163344

forkhead box O4

IDBP-533267

forkhead box O4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184481:
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:101254528-101260873

Strand

Forward strand

Band

Transcripts

ENSMUST00000062000	ENSMUSP00000059420
ENSMUST00000150558
ENSMUST00000138437	ENSMUSP00000116165

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001568	blood vessel development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007050	cell cycle arrest
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007389	pattern specification process
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009888	tissue development
GO:0016525	negative regulation of angiogenesis
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0043066	negative regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048863	stem cell differentiation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0070317	negative regulation of G0 to G1 transition