Version 5.4
Mus musculus Protein: Pts
Summary
InnateDB Protein IDBP-163353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pts
Protein Name 6-pyruvoyl-tetrahydropterin synthase
Synonyms PTPS;
Species Mus musculus
Ensembl Protein ENSMUSP00000034570
InnateDB Gene IDBG-163351 (Pts)
Protein Structure
UniProt Annotation
Function Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003874 6-pyruvoyltetrahydropterin synthase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1338783
InterPro IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein
PFAM PF01242
PRINTS
PIRSF PIRSF006113
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R1Z7
PhosphoSite PhosphoSite-Q9R1Z7
TrEMBL
UniProt Splice Variant
Entrez Gene 19286
UniGene
RefSeq NP_035350
MGI ID
MGI Symbol Pts
OMIM
CCDS CCDS23164
HPRD
IMGT
EMBL AF043225 AF061878 AF061879 AF061880 AK002614 AK146987 BC029013
GenPept AAD02249 AAD15827 AAH29013 BAB22231 BAE27590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca