InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il2rg

Summary

InnateDB Protein

IDBP-163449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il2rg

Protein Name

interleukin 2 receptor, gamma chain

Synonyms

[g]c; CD132; gamma(c); gc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033664

InnateDB Gene

IDBG-163447 (Il2rg)

Protein Structure

UniProt Annotation

Function

Common subunit for the receptors for a variety of interleukins.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0045579	positive regulation of B cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation