InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Muc1

Summary

InnateDB Protein

IDBP-163465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Muc1

Protein Name

mucin 1, transmembrane

Synonyms

CD227; EMA; Muc-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041963

InnateDB Gene

IDBG-163463 (Muc1)

Protein Structure

UniProt Annotation

Function

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, Src and NF- kappaB pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity.

Subcellular Localization

Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions (By similarity). {ECO:0000250}.Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus (By similarity). Some transportation to the nucleus when infected with C.jejeuni. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in a variety of epithelial tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0007565	female pregnancy
GO:0030855	epithelial cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane