Version 5.4
Homo sapiens Protein: GABRA2
Summary
InnateDB Protein IDBP-16351.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA2
Protein Name gamma-aminobutyric acid (GABA) A receptor, alpha 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348897
InnateDB Gene IDBG-16349 (GABRA2)
Protein Structure
UniProt Annotation
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0008503 benzodiazepine receptor activity
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0006810 transport
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030285 integral component of synaptic vesicle membrane
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005432 Gamma-aminobutyric-acid A receptor, alpha 2 subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR01079
PR01615
PR01620
PR00253
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47869
PhosphoSite PhosphoSite-P47869
TrEMBL Q4W5L8
UniProt Splice Variant
Entrez Gene 2555
UniGene Hs.734419
RefSeq NP_001107647
HUGO HGNC:4076
OMIM 137140
CCDS CCDS3471
HPRD 11747
IMGT
EMBL AB209295 AC084352 AC093745 AC095060 AC104072 AK125179 AK289662 AK293466 CH471069 S62907
GenPept AAB27278 AAY40994 BAD92532 BAF82351 BAG54159 BAH11514 EAW93022 EAW93024 EAW93025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca