Version 5.4
Homo sapiens Gene: GABRA2
Summary
InnateDB Gene IDBG-16349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA2
Gene Name gamma-aminobutyric acid (GABA) A receptor, alpha 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151834
Encoded Proteins
IDBP-16351
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-16355
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-474912
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-478338
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-475381
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-479599
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-474838
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-485350
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-479475
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-476647
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-483861
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-475345
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-475521
gamma-aminobutyric acid (GABA) A receptor, alpha 2
IDBP-603161
gamma-aminobutyric acid (GABA) A receptor, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:46248427-46475230
Strand Reverse strand
Band p12
Transcripts
ENST00000356504 ENSP00000348897
ENST00000381620 ENSP00000371033
ENST00000510861 ENSP00000421828
ENST00000514090 ENSP00000421300
ENST00000507069 ENSP00000427603
ENST00000513005 ENSP00000421639
ENST00000510233 ENSP00000422642
ENST00000515082 ENSP00000423840
ENST00000514236 ENSP00000425240
ENST00000514193 ENSP00000425526
ENST00000503806 ENSP00000424362
ENST00000506961 ENSP00000424093
ENST00000507460 ENSP00000422805
ENST00000509716
ENST00000540012 ENSP00000444409
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0008503 benzodiazepine receptor activity
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0006836 neurotransmitter transport
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030285 integral component of synaptic vesicle membrane
GO:0030424 axon
GO:0034707 chloride channel complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000560
View Gene Order
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P47869
TrEMBL A0A024R9X6 D6RB77 D6RBK9 D6RBL7 Q4W5L8
UniProt Splice Variant
Entrez Gene 2555
UniGene Hs.116250 Hs.721015 Hs.721783 Hs.734419
RefSeq XM_006714002 NM_000807 NM_001114175 NM_001286827
HUGO HGNC:4076
OMIM 137140
CCDS CCDS3471
HPRD 11747
IMGT
EMBL AB209295 AC084352 AC093745 AC095060 AC104072 AK125179 AK289662 AK293466 CH471069 S62907
GenPept AAB27278 AAY40994 BAD92532 BAF82351 BAG54159 BAH11514 EAW93022 EAW93024 EAW93025
RNA Seq Atlas 2555

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca