InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med12

Summary

InnateDB Protein

IDBP-163518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med12

Protein Name

mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)

Synonyms

230kDa; Mopa; OPA-1; Tnrc11; Trap230;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085260

InnateDB Gene

IDBG-253359 (Med12)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	68 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0001843	neural tube closure
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007507	heart development
GO:0014003	oligodendrocyte development
GO:0014044	Schwann cell development
GO:0019827	stem cell maintenance
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090245	axis elongation involved in somitogenesis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

MGI:1926212

InterPro

IPR019035 Mediator complex, subunit Med12
IPR021989 Mediator complex, subunit Med12, catenin-binding
IPR021990 Mediator complex, subunit Med12, LCEWAV-domain

PFAM

PF09497
PF12144
PF12145

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AGH6

PhosphoSite