Version 5.4
Mus musculus Protein: Timm8b
Summary
InnateDB Protein IDBP-163588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Timm8b
Protein Name translocase of inner mitochondrial membrane 8 homolog b (yeast)
Synonyms Tim8b;
Species Mus musculus
Ensembl Protein ENSMUSP00000039335
InnateDB Gene IDBG-163586 (Timm8b)
Protein Structure
UniProt Annotation
Function Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Protein Structure and Domains
PDB ID MGI:1353424
InterPro IPR004217 Tim10/DDP family zinc finger
PFAM PF02953
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62077
PhosphoSite PhosphoSite-P62077
TrEMBL
UniProt Splice Variant
Entrez Gene 30057
UniGene
RefSeq NP_038925
MGI ID
MGI Symbol Timm8b
OMIM
CCDS CCDS40624
HPRD
IMGT
EMBL AF196314 AK003382 AK004190 AK012925 AK018718 AK019422 AK169258 BC029239
GenPept AAF13228 AAH29239 BAB22753 BAB23213 BAB28552 BAB31364 BAB31713 BAE41021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca