InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tek

Summary

InnateDB Protein

IDBP-163690.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tek

Protein Name

endothelial-specific receptor tyrosine kinase

Synonyms

AA517024; Cd202b; Hyk; STK1; Tie-2; Tie2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099862

InnateDB Gene

IDBG-163684 (Tek)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0001958	endochondral ossification
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0007160	cell-matrix adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0010033	response to organic substance
GO:0010595	positive regulation of endothelial cell migration
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016337	single organismal cell-cell adhesion
GO:0016525	negative regulation of angiogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030097	hemopoiesis
GO:0030334	regulation of cell migration
GO:0031100	organ regeneration
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034446	substrate adhesion-dependent cell spreading
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627	response to estrogen
GO:0045765	regulation of angiogenesis
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0046777	protein autophosphorylation
GO:0048014	Tie signaling pathway
GO:0051259	protein oligomerization
GO:0051591	response to cAMP
GO:0051894	positive regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:1902533	positive regulation of intracellular signal transduction
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0001725	stress fiber
GO:0005884	actin filament
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0005911	cell-cell junction
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:98664

InterPro

IPR000719 Protein kinase domain
IPR000742 Epidermal growth factor-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00008
PF07714
PF00041
PF01108
PF10430

PRINTS

PR00109

PIRSF

SMART

SM00181
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt