InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Traf1

Summary

InnateDB Protein

IDBP-163732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Traf1

Protein Name

TNF receptor-associated factor 1

Synonyms

4732496E14Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028234

InnateDB Gene

IDBG-163730 (Traf1)

Protein Structure

UniProt Annotation

Function

Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:2001236	regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:101836

InterPro

IPR002083 MATH
IPR008974 TRAF-like
IPR012227 TNF receptor-associated factor TRAF

PFAM

PF00917

PRINTS

PIRSF

PIRSF015614

SMART

SM00061

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P39428

PhosphoSite

PhosphoSite-P39428

TrEMBL

UniProt Splice Variant

Entrez Gene

22029

UniGene

RefSeq

XP_006497909

MGI ID

MGI Symbol

Traf1

OMIM

CCDS

CCDS15956

HPRD

IMGT

EMBL

AK029135 AK169515 AK172598 AL929068 CH466542 L35302

GenPept

AAC37663 BAC26315 BAE41205 BAE43086 CAM27599 EDL08637